Showing posts with label genetics. Show all posts
Showing posts with label genetics. Show all posts

Friday, August 9, 2013

The Maastricht Hamburger

A hundred and one years ago a French scientist named Lewis Carrel started growing a chicken heart. Nothing unusual about that, except this bit of chicken meat wasn't inside a chicken.

It was in a laboratory in New York City, run by the Rockefeller Institute. The lab, that is. As far as the Lemming knows the Rockefeller Institute doesn't run New York City.

The Real 'Immortal' Chicken Heart

Ten years later, chickens hatched when Lewis Carrel started his experiment had died of old age: those that hadn't wound up as chicken soup or obscure ingredients in canned food. Carrel's chicken heart kept beating.

Actually, it wasn't a complete chicken heart: but the bit of undying poultry was beating, just as if it was inside a bird. Lewis Carrel wasn't the chap who wrote the Alice books, by the way. That was Lewis Carroll, he was English, his name wasn't Carroll, and that's another topic. Topics.

In 1946, 34 years after it began, folks at the Rockefeller Institute threw the still-living experiment away. Excitement over the prospects of immortality, at least for chicken hearts, faded:
That's the official story, anyway. Now, in the spirit of 100-proof conspiracy theories, is what the Lemming thinks might have happened.

Good Enough for a Story

Lewis Carrel really is Lewis Carroll. He's a space alien secret agent currently masquerading as an "America's Next Top Model" judge. The immortal chicken heart is still alive, working as a CIA spy but really conspiring to disrupt America's economy by organizing fruit flies in California.

- Or -

The CIA/FBI/Big Oil/Big Peanut/whatever assassinated Lewis Carrel and stole the secret formula that was keeping the chicken heart alive. The Rockefeller Institute threw the immortal chicken heart away because they're part of the conspiracy.

No, the Lemming doesn't believe that. At all. Either of those whoppers might make a good story: maybe along the lines of "Bud Abbott and Lou Costello Meet Frankenstein" or "Attack of the Killer Tomatoes"

More of the Lemming's take on conspiracy theories and getting a grip:

Return of the Immortal Chicken Heart: Sort Of

Some of their laboratory (pronounced 'lah-bore-ah-tor-ee) equipment might look like props from " 'Plan 9 From Outer Space' Meets 'Earth vs. the Flying Saucers,' " but Mark Post's hamburger special is very real.


(from www.maastrichtuniversity.nl/web/file?uuid=a5668f05-839f-4007-ae18-29f40d3608a1&owner=c485ea3c-7a41-4eed-b905-19507dc8ee84 (August 8, 2013))
"Electrical stimulation of muscle cells (left panel) matures early muscle cells (middle panel) into mature skeletal muscle which shows typical transverse striations (right panel, arrows) based on abundance of contractile protein units."

Post and two technicians used a few cells, a lot of science and about 250,000 euros - $325,000 - to grow enough "cultured beef" for a hamburger. Food critics said it was a bit lean, but otherwise quite passable.

Don't look for this at the corner grocery any time soon. The $325,000 burger was a prototype, and there's a lot of work left before cultured beef is available commercially.

When, or if, that happens, folks can buy beef that's grown on a tiny fraction of the land, and with fewer resources, than 'real' beef from something with hooves that goes "moo."

Aside from all-too-predictable fussing about technology, science, and "The Island of Lost Souls," the Lemming doesn't see a problem with cultured beef.

Allegedly-related posts:
Background:

Tuesday, August 6, 2013

Killer Tomatoes and a Ranting Lemming

As anyone who viewed "The Satan Bug" or "Attack of the Killer Tomatoes" knows, humanity is ever in peril from the deadly dangers of science and new ideas.

There are days when the Lemming feels like cheering on the tomatoes' side of the stadium.

This, however, is not one of those days.

Instead, the Lemming offers some helpful advice to the more timorous specimens of Homo sapiens sapiens.

Beware! Beware!

Humans have been developing 'genetically modified' plants and animals for a long time. What's different now is that some call the old ones "domesticated," and the new ones "GMO." And, inevitably, are afraid of the new ones.

For the benefit of those who wish to avoid all genetically modified plants, here's a short list of plants that humans have modified:
  • Alfalfa
  • Almond
  • Apple
  • Apricot
  • Asian Pear
  • Azuki Bean
  • Banana
  • Barley
  • Beet
  • Blackberry
  • Blueberry
  • Breadfruit
  • Carrot
  • Cashew
  • Cassava
    • (aka manioc, yuca)
    • (requires special processing to be edible)
  • Cherry
  • Chestnut
  • Chickpea
  • Citron
  • Clover
  • Coconut
  • Common Bean
    • (including pinto bean, kidney bean and others)
  • Common Medlar
  • Cranberry
  • Currant
  • Durian
  • Eggplant (aubergine)
  • Ensete
  • Fig
  • Finger Millet
  • Fonio
  • Foxtail Millet
  • Gourds
  • Grape
  • Grapefruit
  • Hazelnut
  • Huckleberry
  • Jackfruit
  • Lemon
  • Lentil
  • Lima Bean
  • Lime
  • Little barley
    • (Hordeum pusillum, central US pre-Columbian)
  • Loquat (Japanese medlar)
  • Macadamia
  • Maize
    • (called corn in the U.S.)
    • Old domesticated plant
      • Found in countless variations throughout the Americas
  • Mango
  • Maygrass
    • (Phalaris caroliniana, central US pre-Columbian)
  • Melon (several species)
  • Mung Bean
  • Oats
  • Olive
  • Orange
  • Papaya
  • Parsnip
  • Passionfruit
  • Pea
  • Peanut
  • Pear
  • Pearl Millet
    • (predominantly in African cultures, also for beer brewing)
  • Pecan
  • Peppers
  • Pistachio
  • Plum
  • Pomelo
  • Potato
  • Proso Millet
  • Pumpkin
  • Quince
  • Radish
  • Raspberry
  • Rice
  • Runner Bean
  • Rye
    • (used in Eastern Europe Countries, and for alcoholic beverages)
  • Sorghum
  • Spelt
  • Squash
    • (e.g., Cucurbita pepo, multiple varieties)
  • Strawberry
  • Summer Squash
  • Sweet Potato
  • Tangerine
  • Taro
    • (requires special processing to be edible)
  • Teff -- Ethiopia (also tef)
  • Tomato
  • Triticale
    • (Secalotriticum spp.)
    • Hybrids between wheat and rye.
  • Turnip
  • Velvet Bean
  • Walnut
  • Wheat
  • Winter Squash
  • Yam
  • Zucchini
(Source: "Domesticated Plants," Wikipedia)

Related posts:

Monday, October 31, 2011

Chimps, Genes, and Reading Past the Headline

" 'Junk' All That Separates Humans From Chimps"
Science - SCITECH, FoxNews.com (October 27, 2011)

"We all are the one percent, apparently.

"Scientists have long been baffled by the genetic similarities between humans and chimpanzees, which share up to 99 percent of the same DNA despite our vast differences in appearance and ability -- baffled until now, that is. Researchers have determined that the only thing that separates us from chimps is a tiny bit of 'junk DNA.'..."

No, Really: This Makes Sense

At that point, the Lemming didn't know what to expect. Between folks who desperately want to believe that the universe is maybe 6,000 years old, and others determined to believe that humanity is a cancer in Mother Nature, there's been a lot of nonsense flung around the marketplace of ideas.

That "tiny bit" and "junk DNA" suggested that this article might be of the 'human beings are nothing but hairless chimps' variety.

So the Lemming kept reading. Hey: that's the only way to find out if it's worth writing about.

Turns out, "junk DNA" is what odd bits of code in the human genome were called. The Lemming will get back to that.

"...Led by Georgia Tech professor of biology John McDonald, a new study has verified that while the sequence of genes between humans and chimpanzees is nearly identical, Chimpanzees have certain gaps in their genome. In humans, those gaps are filled with what is known as 'junk DNA.' The findings are reported in the most recent issue of the online, open-access journal Mobile DNA.The research could go a long way in answering a universal question -- what makes us so different?

" 'Let's say intelligence is your ability to compose poetry, symphonies, do art, math and science,' astrophysicist Neil deGrasse Tyson explained at a talk at St. Petersburg College. 'Chimps can't do any of that, yet we share 99 percent DNA.'..."

One of the big questions, given how genetically similar chimps and humans are, is why we're so radically different. Assuming that the answer is strictly in our DNA, that means that the "junk DNA" may not be quite as junky as it's assumed to be.

'We Don't Understand It, So It's "Junk"?'

There's an explanation, of sorts, for how that 1 percent got called "junk." Basically, it's because researchers didn't know what it did. Back to that article, again:

"...For years, scientists assumed the opposite, that this junk DNA did very little. By definition, the sequences have had no known biological functions, such as encoding for protein sequences.

"But McDonald's research indicates these bits of seemingly random code act as important regulators within the human genome, serving as on and off switches, activating important genes and regulating how they are expressed...."

The Lemming isn't sure that it's quite appropriate to call something "junk," because a researcher doesn't understand what it does. On the other hand, "junk" is a whole lot easier to say - and shorter - than something like "seemingly random sequences," so maybe it's a good choice after all.

Anyway, this is a fascinating twist in our studies of human genetics. For the Lemming: your experience may vary.

Somewhat-related posts:
More related posts:

What the Lemming thinks about science, religion, and getting a grip:

Friday, October 14, 2011

Mutant Mice Shed Light on Intestinal Bacteria

"Feedback Loops Keep Gut Bacteria Calibrated"
Ars Technica, Wired (October 14, 2011)

"We tend to get overly focused on bacteria that are trying to kill us (and there's no shortage of those), but there are large populations of bacteria that live in or on us without causing any problems, and some of them are even helpful. This is especially true in the gut, where bacteria help us with the food we eat and provide some essential nutrients; there's even evidence that our gut bacteria can influence our behavior. This creates a bit of a challenge for the immune system, which needs to kill harmful bacteria and avoid killing helpful ones—but still keep their numbers in check. This involves a degree of interaction between the immune system and the bacteria.

"A study in yesterday's Science has described a new way that the gut and bacteria interact to keep things from getting out of hand. Cells in the gut sense when the bacteria get too close, and produce a peptide that kills some of them off when they do. This keeps the space around the cells of the small intestine free of bacteria, which in turn keeps the bacteria from setting off a full-blown immune response...."

The research involved fiddling with mouse genes and seeing what happened. The article is fairly easy reading, but the Lemming wouldn't necessarily recommend perusing it just before a meal. Unless you're on a diet. Or don't mind thinking about the cellular nuts and bolts of digestive activity while you eat.

Fascinating stuff, for the Lemming. Your experience may vary.

Maybe someday medical professionals will realize that antibiotics kill intestinal microcritters, that this messes with normal digestion, and that there's an easy fix available: acidophilus, and that's another topic.

Sort-of-related posts:

Saturday, October 2, 2010

Pink Hippo? Don't Worry: I See It, Too

"Rare Pink Hippo Found in Kenya"
FOXNews (October 1, 2010)

"Seeing pink elephants may mean you're drunk. Seeing pink hippos? You must be in Kenya.

"On a recent expedition to the Masai Mara in Kenya, nature photographers Will and Matt Burrard-Lucas spotted the unusual beast. Pink hippos have previously been seen on only a handful of occasions, largely in Uganda, they said.

"In a post on their site, Will Burrard-Lucas described the encounter:...."

The hippo may not be an albino, with none of the pigment melanin. Burrard-Lucas thinks it's leucistic, another sort of genetic low-pigment situation. There's a fairly well-documented discussion of leucism in the Wikipedia.

The Lemming hopes that the pink hippo's able to handle abundant sunshine better than human beings who are similarly lacking in pigmentation. It'd take a whole lot of sun block to keep that critter covered.

Come to think of it, maybe that's what those oversize freckles on its back are about.

That pink hippo may be on its way to being a sort of tourist attraction, and could use a name. The Lemming suggests "Pinky." Unimaginative: but descriptive.

Tuesday, August 24, 2010

Mutant Bananas: A Pretty Good Idea, Actually

"Bananas Get Pepper Power"
Emily Sohn, Earth News, Discovery News (August 23, 2010)

"Bananas might have gained a new weapon against a devastating disease: The green pepper.

"By genetically modifying bananas with two green pepper genes, scientists have managed to give bananas resistance to Banana Xanthomonas Wilt (BXW), a bacteria that is sweeping through plantations in East and Central Africa. BXW causes about half a billion dollars in damage each year.

"There is currently no good way to stop BXW. There are no varieties of banana that are resistant to it. And there are many other diseases like it spreading worldwide.

" 'Once this disease is in the field, that's an absolute loss because farmers cannot save anything,' said Leena Tripathi, a plant biotechnologist at the International Institute of Tropical Agriculture in Kampala, Uganda. 'The economic consequences are quite high.'...

This sounds like a good idea. Particularly considering how important the things are: and not just for making banana splits.

"...Bananas are one of the most important sustenance crops in the world. In Uganda, Tripathi said, a single person often eats more than three pounds of banana a day. In the United States, people eat more bananas than any other fresh fruit, according to the United States Department of Agriculture, averaging about 26 pounds per person each year...."

Bioengineering better bananas: we don't have many options.

One reason that disease spreads so quickly in banana plantations is that the trees in a plantation are usually genetically identical to each other. Bananas can't reproduce sexually: they don't make seeds that will grow.

That means that it's impossible to breed new strains of bananas. The plants don't breed.

The good news is that we've now got ways to take genes from one creature and put them in another. Sounds spooky, but it's pretty much the same sort of thing we've been doing for millennia, by breeding plants and animals. And, for that matter, grafting the branches from one tree onto another's trunk or roots.

Anyway:

"...In 2005, Tripathi and colleagues started investigating the potential of two genes from green peppers that have been infused into other plants and have provided resistance to bacterial diseases. In lab conditions, they found that normal bananas developed severe symptoms of BXW in just 12 days.

"Six out of eight lines of their transgenic bananas, on the other hand, developed no symptoms at all. They reported some of their findings in the journal Molecular Plant Pathology...."

Provided that the disease-resistant bananas don't produce allergic reactions in humans, or have other problems: looks like folks who depend on bananas for their food and livelihood will get a break soon.

Related posts:

Friday, August 6, 2010

Ötzi the Iceman's DNA

"Gene Map to Give Insight into 5,200-year-old Iceman"
LiveScience (August 5, 2010)

"Iceman, the Neolithic mummy found accidentally in the Eastern Alps by German hikers in 1991, has offered researchers all sorts of clues to life 5,200 years ago, from his goat-hide coat to the meat and unleavened bread in his stomach to the arrow wound in his shoulder.

"Now, scientists stand poised to find out a whole lot more about Iceman, who also goes by Ötzi, Frozen Fritz and Similaun Man.

"They recently finished sequencing the Iceman's genome, which took about three months – a feat made possible by whole genome sequencing technology. With that map of his genes in hand, researchers are moving onto to a whole new array of questions, according to Albert Zink, head of the European Institute for Mummies and the Iceman at the European Academy of Bozen/Bolzano (EURAC) in Italy...."

The researchers should be able to work out the color of "Ötzi," the Iceman's, eyes and hair; whether disease left a mark on his genes, and how his immune system worked. All of which will help us understand what one person was like, a little over 5,000 years ago. Which in turn will help scientists figure out what diseases people dealt with then, how they lived - and how that connects with who we are today.

They've also mapped his mitochondrial DNA - which let them check for living relatives in his maternal lineage. (Background: We get the DNA for our cells' mitochondria from our mothers, the DNA in our cells' nuclei is a mix of our mother's and father's DNA.) So far, they've found no living people whose mitochondrial DNA matches the Iceman's. Which means that there aren't any - or that living maternal descendants are rare.

Once they've got his nuclear DNA ready for comparing to people alive today, they'll start checking folks living in the general area where his body was found - working on the assumption that his descendants wouldn't have moved all that far in 5,200 years.

Which, considering that I'm on the other side of an ocean from most of my ancestors of that period - is quite an assumption. Still, if they're going to check: they need to start looking somewhere.

Related posts:
Related posts, at

Thursday, August 5, 2010

Sea Sponge Genes: More Interesting Than You'd Think

"Sponge species sheds light on animal evolution"
The Hindu (August 5, 2010)

"What is so unique about sea sponges that scientists should care to sequence its genome? Simply put, sea sponges are considered the oldest surviving species of the multicellular metazoan lineage.

"Hence studying their DNA can help in identifying the genetic innovations that enabled transition from single-celled to multicellular life (metazoan animals) some 600 million years ago. Metazoan animals make up a major portion of the animal kingdom.

"Not 'true animals'

"Sea sponges do not have a gut and nervous system, and are hence not generally considered as 'true animals.' Yet, scientists are of the opinion that other multicellular metazoan animals evolved from sponge-like ancestors...."

A close look at the sea sponges' genes showed a "developmental toolkit" that could have let them develop muscles and nerves - although they don't.

I was impressed that sea sponges are genetically similar to other multicellular animals, even though they branched off from the rest more than 600,000,000 years back. It seems to be another case of 'things happened earlier.'

Related posts:
Related posts, at

Thursday, June 17, 2010

Brown Eyes, Blue Eyes, 'Dominant' Faces and a New Mystery

"Study of Dominant-Looking Men Yields Surprising Result"
LiveScience (June 15, 2010)

"There's something in the faces of brown-eyed white men that makes them come off as more dominant than their blue-eyed peers, a new study suggests. And it isn't their eye color.

"Czech researchers asked a group of 62 people to look at photos of 80 faces – 40 men and 40 women - and rate them for dominance. Then the investigators Photoshopped the faces so the brown eyes were replaced with blue ones and vice versa. A separate group of participants rated the altered images for dominance.

"The results were the same in both cases: Faces of brown-eyed men were rated more dominant than those of blue-eyed men, even when their eyes weren't brown...."

Right now, this line of research is in the 'whaddayaknow!' category. It's interesting, intriguing, suggestive: and very much in need of more data.

"...The effect, which didn't hold for female faces, may have something to do with the shape of brown-eyed men's faces, said study researcher Karel Kleisner of Charles University in Prague. On average, brown-eyed men had broader chins and mouths, larger noses, more closely spaced eyes and larger eyebrows than blue-eyed men...."

The idea that one sort of face - when it's on a man - looks more "dominant" than another is nothing new. The Lemming thinks that the scientific community is coming to grips with the idea that men and women aren't equivalent (July 30, 2009), so that part of the research isn't so much of a surprise.

The linkage of facial characteristics and eye color? Here's what's in the article:

"...More mysterious is why eye color would be so closely associated with facial type, the researchers say...."

Anybody who's seen a lot of Swedes and a lot of Koreans - but I'm getting off-topic. The bottom line is that it looks like there's a pattern that researchers haven't noticed before, in what people look like: on average.

Appearance, Socialization, and Eyes

I've got a personal interest in blue-eyed people, since I'm one of them. That's my eye, to your right.

It's likely enough that eye color could, on average, influence how people act toward each other. It also looks like what researchers know is more speculation than actual evidence. For example, the article says blue-eyed children might be treated as if they're a little younger than their normal peers. Or, not.

What's even more interesting, for me, is the probability that blue eyes - and whatever else goes with them - are a new wrinkle for humanity. Last excerpt from the LiveScience article:

"...Researchers believe blue eyes didn't exist until sometime between 6,000 and 10,000 years ago, when a genetic mutation emerged that reduced production of the brown pigment melanin in the iris. Before that, everyone had brown eyes.

"There are now half a dozen different genes that influence whether someone will have blue or brown eyes. One possibility, according to the researchers, is that these same genes that confer eye color have other effects on the body or are in close proximity to other genes that do...."

Another Mystery to Unravel

Over the last half-century, people have learned quite a lot: about how stars work; what's in our genes; and what glial cells may be used for. Along the way, we've discovered new fields that we didn't know existed before. Given the choice between being frustrated at the difficulty of keeping up and enjoying the flow of new knowledge, I'll the excitement of discovery.

Not-entirely-unrelated posts:
Related posts, at

Sunday, June 13, 2010

Attack of the Mutant Eucalyptus Trees!

"Genetically Modified Eucalyptus Trees Ignite Controversy"
Earth News, Discovery News (June 9, 2010)

"Eucalyptus trees are good for making paper. They are terrible for just about everything else – soil, insects, plants, and water.

"A paper company teamed up with ArborGen, a biotechnology organization, to genetically modify the trees to withstand freezing temperatures. The U.S. Department of Agriculture has just approved ArborGen's request to plant various test forests across seven southern states.

"Environmentalists are up in arms about the decision.

"Nicknamed 'America's Largest Weed,' it comes as no surprise that communities are worried about introducing the eucalyptus into new environments, which include 300 acres of test sites in Alabama, Florida, Georgia, Louisiana, Mississippi, South Carolina and Texas...."

One word: Kudzu.

Or: 'Raising giant mutant weeds? What could possibly go wrong?'

Or: Rabbits? In Australia? What could possibly go wrong?

Or: Shut down the coolant pumps? What could possibly go wrong?1

As a rule, I'm not terribly afraid of 'frankenfood,' 'genetic engineering,' or cows. Humanity has been dealing with "artificial life forms" like macaroni wheat and domestic chickens for a very long time.

In this case, though, I think the "environmentalists" may have a point.

What's missing in the article is the connection between eucalyptus trees and those cute-looking koalas. Which are, of course, endangered. Maybe environmentalists who noticed the koala connection blew a fuse, trying to reconcile 'save the delicate North American ecosystem' with 'save the endangered koala.'

What's worrisome about the mutant eucalyptus trees is that the fellows who engineered them are pretty sure that they probably won't make as many seeds as their wild counterparts; probably won't be quite as toxic; and shouldn't spread the way rabbits did, when cony-loving Britishers introduced the critters to Australia. Where they multiplied like, well, like rabbits.

Joking aside, I think field-testing these 'safe' eucalyptus trees has "bad idea" written all over it.

Vaguely-related post:Quite unrelated post:About Koalas and Kudzu:
  • "Koala"
    Mammals, San Diego Zoo
  • "Kudzu"
    National Invasive Species Information Center, National Agricultural Library, United States Department of Agriculture

1 Remember Chernobyl?

Friday, May 7, 2010

Neanderthals and Me: New Data About Old Relatives

"Neanderthal Genome Shows Most Humans Are Cavemen"
Wired Science (May 6, 2010)

"After years of anticipation, the Neanderthal genome has been sequenced. It's not quite complete, but there's enough for scientists to start comparing it with our own.

"According to these first comparisons, humans and Neanderthals are practically identical at the protein level. Whatever our differences, they're not in the composition of our building blocks.

"However, even if the Neanderthal genome won't show scientists what makes humans so special, there's a consolation prize for the rest of us. Most people can likely trace some of their DNA to Neanderthals.

" 'The Neanderthals are not totally extinct. In some of us they live on a little bit, said Max Planck Institute evolutionary geneticist Svante Pääbo...."

When I read that "humans and Neanderthals are practically identical at the protein level," I wondered if that meant that humans are practically identical, or humans whose ancestors lived in Europe for the last few thousand years are practically identical. The researchers took ethnicity/ancestry into account:

"...the researchers produced a more immediately stirring result. They compared the Neanderthal genome to genomes of five people from China, France, Papua New Guinea, southern Africa and western Africa. Among non-Africans, between one and four percent of all DNA came from Neanderthals...."

The Wired Science article goes into a fair level of detail about this research. Interesting, if you're into that sort of thing: which I am.

Folks in Africa don't have the Neanderthal heritage: which isn't all that surprising, considering what's been happening for the last 160,000 or so years. ("'Journey of Mankind:' 160,000 Years of Ups and Downs" (November 1, 2007)) From the looks of it, my ancestors had a serious case of 'sand in the shoes,' and moved out of Africa a long, long time ago. Later, finding their way back might have been tricky: and I'm not convinced that the more sensible folks, who didn't go gallivanting off to the ragged edge of nowhere, would have been all that glad to have the crazy ones back.

Gene Pools and Haircuts

I'm not at all surprised to learn that there's physical evidence that there's Neanderthal DNA in my family's gene pool. My ancestors came from places not far from where Neanderthals lived: and I've seem a fair number of folks who don't look all that much different from the gentleman in that picture. Give him a haircut and a suit of clothes - and language lessons - and he probably wouldn't have that much trouble fitting in.

I don't look very much like a Neanderthal, myself: but I don't look like my Campbell forebears, either. My branch of the clan lost the 'wry mouth' that gave us our name several generations back. Change happens.

Related posts:
More:

What's a nice Catholic fellow doing, writing about Neanderthals? Ultra-terse answer: My faith doesn't encourage me to ignore facts or reason. I've discussed this sort of thing before, in another blog:
The word "evolution" evokes very strong emotions in some folks. Emotions and logic don't play well together. As discussed in yet another blog:

Thursday, March 25, 2010

New Member of the Human Evolutionary Family: Or, Not

"DNA Reveals New Hominid Ancestor"
Wired Science (March 24, 2010)

"A new member of the human evolutionary family has been proposed for the first time based on an ancient genetic sequence, not fossil bones. Even more surprising, this novel and still mysterious hominid, if confirmed, would have lived near Stone Age Neandertals and Homo sapiens.

" 'It was a shock to find DNA from a new type of ancestor that has not been on our radar screens,' says geneticist Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. These enigmatic hominids left Africa in a previously unsuspected migration around 1 million years ago, a team led by Pääbo and Max Planck graduate student Johannes Krause reports in a paper published online March 24 in Nature.

"The researchers base their claim on DNA from a finger bone belonging to a hominid that lived in the Altai Mountains of central Asia between about 48,000 and 30,000 years ago...."

It's early days, and there isn't anything close to a consensus on what this (apparently) new hominid is, and where they fit in the picture of our origins.

There's a fair amount of detail in the article, about this particular find, what scientists are saying about it, and the ups and downs of genetic paleontology.

I'd say that the bottom line is that we don't know: but we're collecting data.

Monday, January 25, 2010

Space Aliens and Killer Monster Robots - From Outer Space; or Pittsburgh

Horses aren't human.

It might be well to remember that, when imagining non-human intelligence. Space aliens, in other words.

I like the original Star Trek series, and have watched many of the series and movies that followed. With few exceptions, though, the space aliens of Star Trek didn't just look awfully human - they thought like humans, too. Sure, Klingons, Vulcans and Ferengi weren't likly to read the same books and go to the same clubs. But they weren't any more diverse than what you'd expect to find in any fair-sized sampling of Homo sapiens sapiens.

So, what will people from other worlds be like? I'm guessing that they'll be like us in some ways: curious, for starters.

They may even be pretty good at carrying on a conversation, if they're social creatures like we are. They probably even have a sense of humor. I suspect that a sense of humor keeps us from killing each other more often than we do.

Even being "social creatures, like we are" doesn't necessarily mean that they'll be all that much like us.

Take horses, for example. They're social creatures. For example, many 'how to care for your horse' manuals say that they need stablemates. In a pinch, a cat will do. But, like I wrote last month, about horses:
"...They're not human.

"Faced with danger, horses run. We're likely to do what most primates do: scream and start throwing things. (Ever see news video of a violent mob?)

"Horses like things to be quiet...."

"...Sure, on Earth the people are screaming, stuff-throwing primates: but that doesn't mean that's the only way things can work."
(Drifting at the Edge of Time and Space (December 9, 2009)
If we do meet aliens whose minds work along equine lines, job one for any human diplomat or negotiator will probably not be their language. It'll be learning to be quiet enough to avoid scaring the living daylights out of them.

And their diplomats and negotiators will have to learn that a screaming human isn't really screaming: it's just acting, well, human. Think American businesspeople and their Japanese counterparts learning to communicate. And they'd probably be indistinguishable to an equinoid. ("I'm terribly sorry, Mister Ambassador: but to me, all humanoids look alike.")

I may have just made up that word, "equinoid." I wasn't thinking so much of aliens shaped like horses, as aliens who thought like horses. On the other hand, horses have used their lips and teeth to untie knots.

Then there's the possibility that the space aliens may be really alien.

Just How Alien Would Space Aliens be?

I found a Space.com article from last year, with some pretty good ideas. And a few all-too-familiar assumptions. Here's how it started:
"What Will Aliens Really Look Like?"
Seth Shostak, Senior Astronomer, SETI Institute Space.com (July 16, 2009)

"According to Genesis 1:27, 'God created man in His own image.' OK, but what about all the other intelligent, cosmic inhabitants? Well, Hollywood has taken care of that. It has created aliens in man's image.

"It's hardly a major revelation to point out that most movie aliens bear a strong likeness to humans...."
I've discussed the "in His own image" idea from a Catholic perspective in another post. (" 'God Created Man in His Image' wasn't Written by An American," A Catholic Citizen in America (January 25, 2010))

The writer of that article made some pretty good points. Convergent evolution, he pointed out (I know: but "Seth Shostak" would be an - unusual - name for a woman), might very well mold many or most intelligent, tool-using creatures into a form not all that much different from our own.

That may be so. The three times that vertebrates grew wings - pterosaurs, birds, and bats - the final result was pretty much the same. Forelimbs became wings. Nobody would mistake one of those creatures for either of the other two - although it turns out the pterosaurs had fur. But again, the basic plan is pretty much the same.

On the other hand, I can't see any reason why people couldn't use tools and be shaped like the bipedal dinosaurs - or squids, when it comes to that.

The first two thirds, roughly, of the article is mostly about how aliens might be shaped. The closest to a discussion of their psychology is this:
"...Their behavioral cues are familiar, and you can tell if their game plan is to be amorous or aggressive. (In most movies, these are their only options.)..."
(Space.com)

Attack of the Killer Robots from Pittsburgh

Then, the writer made what I think is a fairly valid point. The space aliens we meet may not be organic beings. I don't mean 'silicone-based life forms.' The aliens might be machines.

That's not at all unlikely, I think. Look at how we're exploring the Solar system right now: A pair of robots on Mars, more in orbit in various places. People from elsewhere might very well take the same approach. Or, maybe, the people would be machines. That's been a science fiction staple for decades. Generations. ("Men Martians and Machines," Eric Frank Russell (1955), for example - and that built on established conventions)

So has an all-too-familiar set of assumptions. Here's how the writer leads into his discussion of machines as people.
"...Well, using our own experience as a guide, consider a human development that seems likely to take place sometime in the 21st century: we'll invent machine intelligence. Some futurists figure this dismaying development will take place before 2050. Maybe it will take twice that long. It doesn't matter. By 2100, our descendants will note that this was the century in which we spawned our successors...."
(Space.com)
I don't know how old Seth Shostak, the SETI Institute's Senior Astronomer, is. If he's even close to my age, he really should know better.
Artificial Intelligence is Just Around the Corner - for Decades
I was born during the Truman administration, and remember when "2001: A Space Odyssey" hit the silver screen in 1968. The HAL 9000 computer was a science fiction staple: an intelligent, sentient, self-aware computer. Who was insane. Homicidal insanity.

in 1968, the idea that there would be thinking computers in 2001 didn't seem very strange. Experts by the bushel were saying that it would only be a decade or so before we had artificial intelligence.

It's 42 years later, and now I read that we'll have devices like the HAL 9000 computer and C3PO in fifty years.

And that they'll take over.
A Person Can Learn a Lot from the Movies
I can see where the SETI Institute's Senior Astronomer could get that idea. I've been watching the movies off and on for decades: and I've learned a lot.

I've learned that biological warfare and killer bees would kill us all. If the bees didn't explode a nuclear reactor near us first. Even if we survived that, we'd be a handful in an apocalyptic post-nuclear-holocaust wasteland, beset by monster frogs and mutants.

It wasn't all doom and gloom in the movies, of course. There was "Star Wars" in 1977: but that was 'merely escapist entertainment.' Not serious at all. And "Hell Comes to Frogtown" was? Never mind. I don't think anyone took that one seriously.

I don't think that the Senior Astronomer learned his science from Hollywood: but I think there's a chance that he absorbed quite a bit from popular American culture over the last few decades.

I made a list of relatively memorable science fiction movies from the mid-sixties to the present, for another blog. (Drifting at the Edge of Time and Space June 30, 2009) Adding a few about killer robots (and/or computers), here's an update of that list: These movies were drawing on a venerable tradition that included "Robot Monster" (1953) and "The Phantom Creeps" (1939).

A brief digression: Tales of Future Past have some decent still photos from "The Phantom Creeps." The movie was a dramatic account of a mad scientist: "With the power of a radioactive meteor he discovered, his invisibility belt, ray gun, and killer robot spiders he plans to conquer the world."

Back to the topic at hand.
HAL 9000, Skynet, and The Matrix
It's hard, sometimes, to shake the idea that a whole lot of Americans are Luddites. I don't mean 19th English workmen who broke machines: "any opponent of technological progress". (Princeton's WordNet)

I mean to say: "...By 2100, our descendants will note that this was the century in which we spawned our successors...."

Okay, Skynet made a pretty spooky evil mastermind for the Terminator movies. And "The Matrix" is supposed to be real intelligent. (I've yet to see the latter, by the way, in its entirety - an oversight which I intend to correct this year.)

I've not putting down any of the movies I've cited. I am not one of the folks who objects to entertainment on principle. But I try to make distinctions between what makes for a good story, and what's plausible.

I might be more concerned about robot monsters enslaving humanity, if artificial intelligence hadn't been 'just around the corner' for my entire adult life. And if the AI we have were more - intelligent.

As a Cyborg, I'm Biased

I might be more concerned about humanity's becoming machine-like, if I weren't part machine already.

I've got a few teeth that are still original equipment, but a fair portion of what I chew with is artificial. I've got metal and plastic where my hip joints used to be, a plastic mesh that held my belly together after some work was done in there, and I'm focusing on my computer's monitor through a clip-on set of lenses.

All of that's nothing unusual at all. Now.

Which is my point. I look as human as my ancestors, a thousand years back: providing I take my glasses off and keep my mouth closed. But a noticeable percentage of me is machinery of one sort or another.

Even my brain's been altered, chemically. I was diagnosed with major depression a few years ago. Thanks to medication, I don't have to constantly fight the controls to think clearly - for the first time in over 45 years.

I'm not, quite, a cyborg. Not in the sense of "a human being whose body has been taken over in whole or in part by electromechanical devices" (Princeton's WordNet) But partly artificial? Yes.

And I have no problem with that. My distant ancestors, some of them, might have been freaked out to learn what has been done to me: but I see being able to walk without pain, see clearly, concentrate better, chew my food, and have something that kept the insides of my abdomen where they belong - inside - as enhancements. I certainly don't see having artificial parts as being "taken over" by machinery.

The brain chips that Intel says it's coming out with in about ten years (yes, I believe them): that's a bit different. People who have an interface between their brains and prosthetic limbs will, arguably, be cyborgs. So will stroke victims whose damaged or destroyed circuits are replaced with artificial ones.

I discussed this sort of thing last month:
...Will Brain Implants Be Misused?
"What is that, a trick question? Of course they'll be misused. People misuse things. People have killed other people with rocks. That doesn't make the rocks bad.

"Direct neural interfaces are a new technology, and there'll almost certainly be an awkward period while we learn how to use them, and set up rules so that everybody's more-or-less on the same page about how they should be used. "But, I'm looking forward to the things...." (Apathetic Lemming of the North (December 2, 2009))
I don't think that Science and Technology (capitalized, of course) will Solve All Our Problems. But I'm not afraid of science and technology.

Robots, Artificial Intelligence, and Fido

About 'spawning our successors?' In a way, we've been through this before.

Dogs are man's best friend, right? With a few psychotic exceptions, of course.

That shouldn't be much of a surprise. We've recently discovered that dogs are mutant wolves. Something happened to the genes of a few wolves that made their offspring just simply dote on human beings - and made them a bit less smart that your average wolf.

Yes: people were "primitive" back then. No white lab coats, no test tubes, certainly no electron microscopes. It's a bit hard, though, for me to imagine that a breed of stupid wolf 'just happened' to come along - that got along well with human beings.

I think we made dogs. "Domesticated," if you prefer. I also think that the process was a whole lot easier than it might have been, since wolf packs work roughly the same way human families do, and a wolf cub could bond with a human family, just like he or she would bond with the pack.

But I think we're the reason dogs are so, well: dog-like.

People have kept wolves as pets, but that's rare. In general, people and wolves don't mix. Dogs? Well, they're "man's best friend."

Artificial intelligence won't be like Fido. We've already got dogs - with over a hundred thousand years' worth of tweaking invested. We don't need a replacement.

But human beings replaced by AI? I think that's about as likely as the fictional C3PO plotting to take over the restored Republic.

As for human beings becoming cyborgs? That's been happening for centuries. And somehow, we're still as human as we ever were: for good or ill. Related posts: More:

Saturday, November 14, 2009

Tofu Turkeys, Genetically Altered Foods, and the Evil Eye

An American holiday, Thanksgiving, is coming up. I look forward to Thanksgiving as a time when the extended family comes together to talk, have fun, and eat a festive meal together.

I've also long since come to terms with the fact that I'm a human being - and that human beings are opportunistic omnivores. Although it's possible for us to stay relatively healthy on a diet devoid of animal protein, I think there's no reasonable point in the exercise.

Unless a person has health issues: A relative of mine is a strict vegetarian, because of a heart condition. Doctor's orders.

I don't mind the silly side of Thanksgiving. It's given me an excuse to make a few motivational posters.

Like this one, inspired by memories of my earnest, sensitive fellow-students back in the 'good old days:'





Researching a post for another blog, I ran across a recipe for ersatz turkey. The base material is tofu. I'm no huge fan of eating curdled soy milk, but the recipe I found sounded pretty good.

First, from that post, "Tofu Turkey: No Kidding," Loonfoot Falls Chronicle-Gazette (November 13, 2009):

"You may remember Howard Leland, proponent of the 'natural yard,' member of the Asclepias Society member, and defender of zombie ants.

"He's decided that he won't contribute to the annual slaughter of turkeys this year. He told me that he's going to feast on a concoction of tofu, sage, rosemary and thyme. No parsley, though. The recipe also calls for vinegar (balsamic, not that ordinary kind), red wine, Dijon mustard, soy sauce, and a few other ingredients.

"Turns out, 'balsamic vinegar' isn't vinegar at all. It's not made from wine, but from grape pressings that get boiled down and aged. The source I used said that it got popular in America after chefs at upscale restaurants started using it. No wonder balsamic vinegar was new to me...."

Now, that tofu turkey recipe:

"Homemade Tofu Turkey with Stuffing"
About.com: Vegetarian Food

"This Thanksgiving, try making your own homemade tofu turkey, complete with vegetarian stuffing inside. There's a few different steps involved, though the process is very simple. A homemade tofu turkey will be the pride and joy of your vegetarian or vegan Thanksgiving celebration!..."

The recipe doesn't look too hard to follow - although I'd have a time finding the "vegetarian stuffing" they refer to. And, providing you weren't expecting it to taste like turkey, the results could be fun to eat.

If you'd rather eat prefab tofu turkey, there's an outfit that sells a product they call Tofurky®: www.tofurky.com.

As I pointed out in that Loonfoot Falls post, Tofurky® is for people with refined tastes. It's: "Made, naturally, in a very vegan way with no 'genetically engineered foods.' That must take some doing, since soybeans have been a domesticated plant for about 31 centuries now...."

Domesticated Crops and the Evil Eye

It wasn't too long ago that people were worried about the evil eye. Some still do.

But a more up-to-date fashion is the fear of "genetically engineered" foods. They're not "natural," you know.

Which is true. There's nothing particularly natural about most of the foods we eat.

"...My guess is that most people don't think of domesticated plants and animals as 'artificial.' Wheat, domestic chickens, and big, juicy apples have been around for so long that it's easy to assume that they've 'always been there.'

"Besides, 'technology' is something new and cool, right? Not the sort of thing that those serfs and peasants do. Or, these days, those farmers...."
("Hard Science Fiction, Cultural Blinders and Laban's Sheep," Drifting at the Edge of Time and Space (October 29, 2009))

Maize - the stuff that Americans call "corn" - is an artificial life form, developed thousands of years ago in North America. Corn-on-the-cob is grown by plants whose genes were altered by selective breeding.

The method isn't the same as what's done at places like North Dakota State University, but the results are just as artificial: "natural" plants wouldn't have those oversized cobs with huge kernels. Maize looks - and tastes - the way it does, because people wanted it that way.

I think it's a good idea to be careful about what you eat: and this household does quite a bit of cooking 'from scratch,' using foods that haven't been processed all that much since they got separated from the (domesticated) plant or animal that grew them.

Of course, "genetically engineered," as used in the contemporary fashion seems to mean "developed during the last few decades, using techniques that weren't around in my grandparents' time."

Ambivalence toward the new and different is - not new. When I was growing up, I ran into a joke about a little old lady on an airplane. She was clearly not enjoying the flight. She explained her point of view: "People shouldn't fly around. They should be where God intended them to be: safe at home, watching television!"

A century or two from now, my guess is that a fear of "genetically engineered foods" will be like fear of the "evil eye" is now: a quaint cultural quirk, sincerely held by a few; studied by some; and forgotten by many.

Related posts: Background:

Thursday, October 29, 2009

You Mean Germans, Japanese and Kenyans aren't All Alike?!

"Culture (Not Just Genes) Drives Evolution"
Discovery.com (October 28, 2009)

"Culture, not just genes, can drive evolutionary outcomes, according to a study released Wednesday that compares individualist and group-oriented societies across the globe.

"Bridging a rarely-crossed border between natural and social sciences, the study looks at the interplay across 29 countries of two sets of data, one genetic and the other cultural...."

Well, shazam!

I think some of the silly science I had to learn, back in the seventies, was a reaction to the equally silly science of the 19th century. It's good to see that researchers are starting to look at the data, not just what they'd like as results.

This research is exciting, I think, because it's a start at learning more about differences between groups of people around the world. Not 'proving' that one group is better than another - but how and why we're different.

My guess is that this isn't (by far) the last word on how culture and genetics interact.

"...In China and other east Asian nations, for example, up to 80 percent of the population carry this so-called 'short' allele, or variant, of a stretch of DNA known as 5-HTTLPR...

"...it is also associated with the impulse to stay out of harm's way.

"By contrast, in countries of European origin that prize self-expression and the pursuit of individual over group goals, the long or "L" allele dominates, with only 40 percent of people carrying the "S" variant...."

As the late Steve Irwin said, "crikey!"

Vaguely-related posts:

Thursday, July 9, 2009

Another Look at How Some Dinosaurs Grew So Large

"How Dinosaurs Got So Big"
LiveScience (July 6, 2009)

"The secret to mega-dinosaurs' impressive sizes may be that the reptiles used more of their energy for growing and less for keeping their bodies warm compared with some creatures.

"A new model could help explain how some dinosaurs, such as long-necked sauropods, could have achieved masses of around 60 tons — about eight times the mass of an African elephant, the largest land animal alive today.

"The two main factors that determine vertebrate size are the amount of available food and how the creature expends its energy, said researcher Brian K. McNab, a paleontologist at the University of Florida. For example, elephants can be quite large because they feed off grasses, a relatively abundant food supply as opposed to say, the nectar that hummingbirds and bees consume, McNab said...."

The LiveScience article seems to be a pretty good overview of McNab's speculations, and a review, at least, of what we know - and have surmised - about dinosaurs.

I'm not sure if LiveScience over-simplified NcNab's work, or if this really is a fair sample:
"...'I think it was impossible for [dinosaurs] to have really high metabolic rates like mammals and birds, simply because the resources weren't there,' he told LiveScience.

"For example, there were no grasses in the Mesozoic, which are a major food source for herbivores, McNab said...." (LiveScience)
True: grasses didn't exist when these enormous animals did. But without a detailed analysis of the biome those dinosaurs lived in - including data on the caloric and other nutritional values of the plants available - I'm not sure that no grass = no big animals idea is really valid.

But I'm no expert.

The point about larger animals shedding heat less rapidly than smaller ones has been made fairly often in discussions of dinosaur metabolism.

NcNab's speculations are another reason why I think researchers could learn a great deal, if it was possible to grow a living dinosaur. That's an idea that's getting less wildly improbable by the year: "Bringing Back the Dinosaurs: Not a Crazy Idea Any More" (June 29, 2009).

Monday, June 29, 2009

Bringing Back the Dinosaurs: Not a Crazy Idea Any More

"Jurassic Park comes true: How scientists are bringing dinosaurs back to life with the help of the humble chicken"
MailOnline (June 13, 2009)

"Deep inside the dusty university store room, three scientists struggle to lift a huge fossilised bone.

"It is from the leg of a dinosaur.

"For many years, this chunky specimen has languished cryptically on a shelf.

Interesting but useless — a forgotten relic of a lost age.


"Now, with hammer and chisel poised, the academics from Montana State University in America gather round.

"They are about to shatter this rare vestige of the past.

"Why would they do such a thing?

"The answer is that they believe that this single fragment of a beast which stalked the earth untold millions of years ago could hold the key which will unlock the secrets of the dinosaurs...."

The first part of the article is long on drama and short on facts, and may have been intended to draw attention to a television documentary, "Dinosaurs: Return To Life." Something with the same title and subject aired on Discovery Channel - yesterday, I see.

Too bad. It might have been an entertaining - and possibly informative - way to spend an hour. I may catch a re-run, eventually.

Farther down the 'page,' the MailOnline article gets into what makes "Dinosaurs: Return to Life" more than one more docuflick about dinosaurs.

While airlifting a remarkably well-preserved and complete 68 million-year-old Tyrannosaurus Rex skeleton in Montana, a thigh bone was cracked open.

Still, two halves of a thighbone are better than none, so Montana State University professor of palaeontology Jack Horner, palaeontologist Mary Schweitzer and research assistant Jennifer Wittmeyer studied the thing. Schweitzer noticed an odd structure in a piece she'd been given to scrutinize.

Cutting a long story short, there was 68,000,000-year-old T-rex tissue in the bone.

It wasn't exactly fresh, but it was still gooey. The scientists think they may have spotted osteocytes in the mess: bone-growing cells.

The article discusses a number of other points, including mutant chickens at the University of Wisconsin.

My guess is that, between parts of dinosaur DNA that may be recovered from finds like the one in Montana, and what we're learning about the genetic code, it may not be all that long before someone grows a reasonable facsimile of a dinosaur.

Aside from being a subject for media sensationalism, and despite its being raised in what is profoundly not its natural habitat, there would be a great deal to be learned from a living, breathing dinosaur.

And, Jurassic Park notwithstanding, my guess is that the trick would be keeping the creature alive.

More, about studying dinosaurs, at "Trotting With Emus To Walk With Dinosaurs," Science Daily, (October 30, 2006).

Friday, June 26, 2009

Toddler's Stature, Mind, and Teeth, 10-Year-Old's Bones

"16-Year-Old Has the Body
of a Baby
"
myFOX Chicago (June 24, 2009)

"She's 16 years old, but has the body and mind of a toddler.

Years have passed and doctors still can't solve a baffling mystery -- why hasn't Brooke Greenberg aged?

ABC News reports that Brooke is 16 pounds and 30 inches tall. She doesn't speak, but knows how to vocalize sounds to ask for things or express what she likes and doesn't like, just like an infant. Doctors have observed that Brooke's body is growing out of sync. For instance she still has baby teeth, but her bone age is estimated to be 10 years old....
"

I hope that Brooke's family is holding up under the pressure of having a daughter who is that far off the 50th percentile.

Dr. Richard Walker(University of South Florida) and geneticist Maxine Sutcliffe think that there's a genetic reason for Brooke's condition, and they want to find it. If they do, they think we'll know much more about how and why people age.

I wish the doctor well, and don't want to seem like I'm standing in the way of scientific progress, but I hope that Brooke is treated with more respect than I was (Medical Ethics and Human Experimentation: Why I Take it Personally" (February 3, 2009))

This article is a pretty good overview of Brooke's condition, and what may - or may not - be causing it.

More, at "Doctors Baffled, Intrigued by Girl Who Doesn't Age," ABC News (June 23, 2009).

Sunday, April 19, 2009

Charles II of Spain and a Seriously Messed-Up Family

"Inbreeding Was Major Cause Of Fall Of Spanish Habsburg Dynasty"
Science Daily Press Release (April 16, 2009)

"The powerful Habsburg dynasty ruled Spain and its empire from 1516 to 1700 but when King Charles II died in 1700 without any children from his two marriages, the male line died out and the French Bourbon dynasty came to power in Spain...."

Inbreeding: Good For Keeping Power in the Family; Not so Good for the Family

Sounds like the Hapsburgs were in the habit of marrying cousins - and, two times, an uncle and niece - to keep political power in the family. In the short run, it worked. Just one problem: after a while, the family died out.

More, at:

"Inbreeding brought down Spain's Habsburgs: study"
Reuters (April 14)

"Rare inherited genetic disorders worsened by repeated inbreeding may have brought down the powerful Spanish Habsburg dynasty, Spanish researchers said on Tuesday.

"Checks of genealogical charts and analysis of King Charles II's reported health problems suggest he may have had two rare conditions called combined pituitary hormone deficiency and distal renal tubular acidosis, the researchers speculated in the Public Library of Science journal PLoS ONE...."

Charles II of Spain was a mess. He did learn to speak: when he was four. And, the monarch was able to walk: starting at age eight. He died when he was 39, leaving no children.

No wonder he was called El Hechizado ("The Hexed")

Tuesday, April 14, 2009

Depression, Brain Structure, and Heredity - More Data to Crunch

"The depressive brain: it's in the family"
Battling for Health (April 14, 2009)

"The depressive brain is structurally different compared to a non-depresssive brain. And it seems to run in the family. This is reported by scientists at Columbia University. Those with a family history of depression have brains which are, on average, 28% thinner in the area of the right cortex compared to those with out familial history of depression. This difference seems to be evident long before depressive symptoms, if ever, come up. The cortex is the outermost layer of the brain and this thinning of the cortex is also somewhat similar to those observed in patients with schizophrenia or Alzheimer’s disease...."

This was particularly interesting to me, since I've been diagnosed with major depression. I've got a notion that there's more to depression than just the cortical anomalies mentioned in the article, though.

Mostly because I've only got one of the three problems mentioned: "Failure to pick up on social and emotional stimuli." The others (selected, we're told, from a longer list) - problems with concentration and visual memory - are among my strengths.

I hope that doctors and researchers are beginning to realize that not everyone is - or should be - at the 50th percentile.
A tip of the Lemming's hat to PetLvr on Twitter, for referring me to this article.
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